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Description

The resulting linkage is an isoxazole, which is hydrolytically stable and shows similar isosteric character of amide and ester bonds

Similarly, berberine shows anti-apoptotic effects by reducing the overexpression of caspase-3 and Bax/Bcl-2 (Sadeghnia et al., 2017)

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To reduce melanin, the best drinks you may choose are green tea and vitamin C- rich fruit juices 6,14 like lemonade, orange juice, strawberry smoothie, although further research is needed to confirm their depigmentation effects